Cancer is a leading cause of death worldwide, and one of the most feared diagnoses a patient can face. The number of new cases is expected to rise by 70% over the next two decades, but few of us understand what it is, how it affects the body or what can be done to treat and even prevent it. In this illuminating introduction, Dr Paul Scotting explains the science behind the disease and explores the factors that can increase our risk of developing cancer. Fully revised and updated, Cancer: A Beginner's Guide details the latest breakthroughs, cutting-edge developments and promising new strategies that will help us combat and cure cancer in the future.

Cancer Immunotherapy, Volume 165 in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to different approaches to cancer immunotherapy, with this release focusing on TNFR2 in cancer immunology and immunotherapy, From the Hellstrom paradox towards cancer cure, CAR T-cell treatment of T-cell malignancy , Immunotherapy of pancreatic cancer, Cancer stem cell immunology/immunotherapy, Cytokine release syndrome, Tumor cell-based mechanisms of resistance to immune attack, and Mushroom compounds in cancer immunotherapy.

Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment. Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers Provides immediately actionable information - and hopefully also inspiration - to move discovery and clinical application forward Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers

Several medical options in palliative care can have complex moral, religious, cultural, medical and legal issues. These treatment options, such as assisted suicide, rehydration, parenteral nutrition and cardiopulmonary resuscitation have been heavily debated in the literature. Physician-assisted suicide is a controversial topic for debate, with growing pressure from advocacy groups for legalisation in regions that have yet to decide. Currently, there is substantial opposition from concerned medical professionals. However, a school of medical professionals acknowledges that physician-assisted suicide may have a role in terminal care. The debate over the use of artificial nutrition and hydration (ANH) in terminal illness is also contentious despite extensive ethical and empirical research. Advocates for and against ANH both agree that the most compassionate and humane option for patients near the end of life is hospice and/or palliative care. However, many of those who support ANH do not seem to appreciate that the standard palliative practice is to avoid the use of ANH in almost all instances. These topics remain heavily disputed in the medical community. In formulating a satisfactory answer, we need to remind ourselves that we cannot generalise a treatment as a correct or incorrect option. Rather, we need to consider each case individually, weigh the risks and benefits of each treatment, and individually consider treatment options in a multidisciplinary care model.

This is the thirteenth volume in a series which presents current understanding of stem cells and cancer stem cells. This book presents many relevant topics including the different sources of cancer stem cells: the features, roles and clinical potential of stem cells emerge from engaging with this comprehensive work. Chapters explore molecular mechanisms underlying human somatic cell reprogramming to generate induced pluripotent stem cells and provide expert discussion of the advantages and limitations of applications of some of the stem cell types (pluripotent stem cells, neural stem cells). Many advances are explored, including the importance of stem cell markers in diagnosis, the role of stem cells in angiogenesis and a method for isolating multi potent endothelial-like cells from human adipose tissue, to name a few. Readers will also find a consideration of mathematical models and other quantitative tools which could facilitate research and discovery in the field. The editor's preface to the book and the series is particularly helpful in introducing the work presented in this volume. The detailed overviews, practical experience and insights of international expert authors presented in this handbook will be of value to both professional practitioners and scholars in basic research.